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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T3036 | Dydrogesterone | Progesterone Receptor | |
Dydrogesterone is a potent progestogen which can be used in progesterone deficiency studies. | |||
T13703 | Gestonorone Capronate | Prostaglandin Receptor | |
Gestonorone Capronate is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer. | |||
T7537 | Norgestimate | Progesterone Receptor | |
Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive. | |||
T28362 | PF-02413873 | PF02413873 | Progesterone Receptor |
PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis. | |||
T1514 | Norethindrone | Norethisterone | Estrogen/progestogen Receptor , Progesterone Receptor |
Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties... | |||
T8395 | Nomegestrol acetate | Others , Progesterone Receptor | |
Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor | |||
T1596 | Chlormadinone acetate | Gestafortin | Progesterone Receptor , Androgen Receptor |
Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive. | |||
T1541 | Drospirenone | ZK 3059,Dihydrospirorenone | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , COX |
Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. | |||
T6819 | Desogestrel | Org-2969,Desogen,Desogestrelum,Cerazette | Estrogen/progestogen Receptor , Progesterone Receptor |
Desogestrel (Cerazette) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. | |||
T0996 | Ethynodiol diacetate | Ethynodiol acetate,8080 CB | Estrogen/progestogen Receptor , Progesterone Receptor |
Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. | |||
T6713 | Ulipristal | Estrogen/progestogen Receptor , Progesterone Receptor | |
Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. | |||
T5317 | Cridanimod | CMA,XBIO-101,10-carboxymethyl-9-acridanone | Progesterone Receptor , STING , IFNAR |
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. | |||
T2577 | Dienogest | STS 557 | Apoptosis , Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy |
Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therap... | |||
T1490 | Gestodene | SHB 331,WL 70 | Estrogen/progestogen Receptor , Progesterone Receptor |
Gestodene (WL 70) is a progestogen hormonal contraceptive. | |||
T5174 | Nestoron | ST-1435,Segesterone Acetate,Nestorone,Elcometrine | Estrogen/progestogen Receptor , Progesterone Receptor |
Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM). | |||
T0870 | Altrenogest | R2267,RU2267,Allyltrenbolone,A35957 | Estrogen/progestogen Receptor , Progesterone Receptor |
Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone. | |||
T14975 | CJ-42794 | CJ-042794 | Others |
CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-... | |||
T2527 | Ulipristal acetate | Ulipristal,CDB-2914 | Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy |
Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereb... | |||
T2567 | Etonogestrel | 3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives. | |||
T1102 | Mifepristone | C-1073,RU486,RU 38486 | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , NO Synthase , Autophagy |
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist. | |||
T2231 | Estradiol dipropionate | 17-Beta-Estradiol-3,17-Dipropionate | Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Progesterone Receptor |
Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol. | |||
T20720 | Norethisterone enanthate | NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,NSC-9564 | Estrogen/progestogen Receptor |
Norethisterone enanthate (NSC-9564) is a long-acting parenteral progestogen with antigonadotropic effects. | |||
T60056 | Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- | Progesterone Receptor | |
Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- is a progesterone receptor antagonist with antiprogestin effects. | |||
T35054 | Vilaprisan | BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670 | Progesterone Receptor |
Vilaprisan (BAY 1002670) is a novel orally available and selective progesterone receptor modulator (SPRM) with antiproliferative activity against uterine fibroids (UF) and can be used for the study of uterine fibroids. | |||
T7223 | Gestrinone | R 2323 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Gestrinone (R 2323) is a synthetic androgen receptor agonist and ER and progesterone receptor antagonist used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. | |||
TP1862L | [Sar9] Substance P acetate(77128-75-7 free base) | Neurokinin receptor | |
[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP. | |||
T21395 | Finerenone | BAY948862,BAY-948862,BAY94-8862,BAY 94-8862,BAY-94-8862,BAY 948862 | Glucocorticoid Receptor |
Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone (BAY-948862... | |||
T16502 | PF-3882845 | Others | |
PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for ... | |||
T17291 | ZK 216348 | (+)-ZK 216348 | Others |
ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an an... | |||
T28995 | Tosagestin | Org 30659,Org30659,Org-30659 | |
Tosagestin is a progesterone receptor agonist. | |||
T28263 | Org-31710 | Org 31710,Org31710 | |
Org-31710 is a progesterone receptor antagonist potentially for contraception. | |||
T34798 | Telapristone | metabolite of telapristone acetate (CDB-4124) | |
Telapristone, is the active metabolite of telapristone acetate (also known as CDB-4124). Telapristone is a selective progesterone receptor modulator (SPRM) being studied for the treatment of certain progesterone-sensitiv... | |||
T31082 | CP-8668 | UNII-5371O2R79D,CP 8668 | |
CP-8668 is an orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzoindolone skeleton. | |||
T14332 | Asoprisnil | J867 | Others |
Asoprisnil is a selective modulator of progesterone receptor. | |||
T29224 | ZK112993 | ZK-112993,ZK 112993 | |
ZK112993 is an antagonist of human progesterone receptor. | |||
T28264 | Org-33628 | ||
Org-33628, a progesterone receptor antagonist, is used potentially for female contraception. | |||
T27108 | Cymipristone | ZXH951,ZXH 951,ZXH-951 | |
Cymipristone, a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy. | |||
T27662 | JNJ-1250132 | JNJ 1250132,JNJ1250132 | |
JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro. | |||
T16985 | Tanaproget | NSP-989 | Others |
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM), | |||
T25304 | Demegestone | R-2453,Lutionex,R 2453,RU 2453,R2453 | |
Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat lutea... | |||
T19697 | Norgestomet | SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009 | |
Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromol... | |||
T28237 | Onapristone | IVV-1001,ZK 98299,IVV 1001,ZK98299,ZK-98299,IVV1001 | |
Onapristone, a progesterone receptor antagonist, is used potentially for the treatment of breast cancer, advanced prostate cancer, and inducer of vaginal bleeding. | |||
T16396 | OP-3633 | Others | |
OP-3633 is an effective and selective steroidal glucocorticoid receptor (GR) antagonist (IC50: 29 nM). OP-3633 shows low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. It also has an inhibition... | |||
T69895 | Lonaprisan | ||
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; b... | |||
T37319 | 5β-Dihydroprogesterone | ||
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when u... | |||
T68473 | WAY-255348 | ||
WAY-255348 is a potent nonsteroidal progesterone receptor (PR) antagonist. WAY-255348 inhibits the activity of progesterone. WAY-255348 achieves antagonist activity by binding to and subsequently preventing progesterone-... | |||
T28280 | Oxendolone | Roxenone,Prostetin | |
Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of 5α-reducta... | |||
T26669 | Asoprisnil ecamate | J956,J-956,J 956 | |
Asoprisnil ecamate is a selective progesterone receptor modulator. Asoprisnil inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cell... | |||
T19684 | Pregnanolone | SKF 6455,Kabi-2213,Kabi 2213,Eltanolone,Kabi2213,SKF6455 | |
Pregnanolone is a cell membrane modulator potentially for the treatment of pain. Pregnanolone is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA rec... | |||
T39853 | ARD-61 | ||
ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apo... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T0478 | Progesterone | Pregn-4-ene-3,20-dione | Estrogen/progestogen Receptor , Progesterone Receptor , Opioid Receptor , Endogenous Metabolite |
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is require... | |||
T1263 | Levonorgestrel | D-Norgestrel | Others , Estrogen/progestogen Receptor , Progesterone Receptor |
Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. | |||
T5040 | Medroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor | |
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. | |||
T1261 | Medroxyprogesterone Acetate | Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate) | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , Endogenous Metabolite |
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been... | |||
T1429 | 17α-Hydroxyprogesterone | Hydroxyprogesterone,17-OHP,17-Hydroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor , Endogenous Metabolite |
17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to th... | |||
T1284 | Megestrol acetate | SC10363,BDH1298 | Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , HIV Protease , Autophagy |
Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment ... | |||
T7974 | Lynestrenol | Progesterone Receptor | |
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist | |||
T7931 | 16a,17a-Epoxy-4-Pregnen-3,20-Dione | Others | |
16a,17a-Epoxy-4-Pregnen-3,20-Dione is a synthetic progestin, a metabolite of the luteinizing hormone hormone, which acts by binding to the luteinizing hormone receptor. It has been used to study the effects of progestero... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPK-00591 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His) | Mouse | HEK293 Cells |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ... | |||
TMPK-00717 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ... | |||
TMPY-01383 | PRMT6 Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex... | |||
TMPK-00716 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244) | Human | HEK293 Cells |
Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK ... |
カタログ番号 | 製品名 | ||
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L2191 | Anti-Breast Cancer Compound Library | 1939 compounds | |
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; |